The oral manifestations of chronic graft-versus-host disease (cGVHD) in paediatric allogeneic bone marrow transplant recipients

J Oral Pathol Med. 2001 Mar;30(3):148-53. doi: 10.1034/j.1600-0714.2001.300304.x.


The oral manifestations of chronic graft-versus-host disease (cGVHD) in eight allogeneic bone marrow transplant (BMT) paediatric recipients were studied clinically, and lip biopsies were performed in seven of them. A prominent lichenoid reaction was observed in four patients, two with accompanying ulceration. Superficial mucoceles were present in three children. Clinically obvious xerostomia was seen in seven patients. Lip biopsies were positive and correlated with the clinical manifestations. Both clinical and histological findings confirmed the diagnosis of cGVHD. In three additional children, with systemic manifestations indicating cGVHD, the oral mucosa was clinically and histologically normal, and the systemic manifestations were, thus, attributed to drug reactions. The above findings indicate the high value of oral examination in diagnosing or confirming paediatric cGVHD. Superficial mucoceles, reported for the first time in paediatric recipients, seem to be important in the early diagnosis of cGVHD.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Biopsy
  • Bone Marrow Transplantation / adverse effects*
  • Child
  • Chronic Disease
  • Female
  • Graft vs Host Disease / complications*
  • Graft vs Host Disease / diagnosis
  • Graft vs Host Disease / etiology
  • Humans
  • Infant
  • Lichen Planus, Oral / etiology
  • Lip / pathology
  • Male
  • Mouth Diseases / etiology*
  • Mouth Mucosa / pathology*
  • Mucocele / etiology
  • Xerostomia / etiology