Conservation of the rat X chromosome gene order in rodent species

Chromosome Res. 2001;9(1):61-7. doi: 10.1023/a:1026795717658.


We constructed the comparative cytogenetic maps of X chromosomes in three rodent species, Indian spiny mouse (Mus platythrix), Syrian hamster and Chinese hamster, using 26 mouse cDNA clones. Twenty-six, 22 and 22 out of the 26 genes, which were mapped to human, mouse and rat X chromosomes in our previous study, were newly localized to X chromosomes of Indian spiny mouse, and Syrian and Chinese hamsters, respectively. The order of the genes aligned on the long arm of human X chromosome was highly conserved in rat and the three rodent species except mouse. The present results suggest a possibility that the rat X chromosome retains the ancestral form of the rodent X chromosomes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Chromosome Mapping*
  • Cricetinae
  • DNA, Complementary / metabolism
  • Evolution, Molecular
  • In Situ Hybridization, Fluorescence
  • Mesocricetus
  • Mice
  • Models, Genetic
  • Rats
  • Species Specificity
  • X Chromosome*


  • DNA, Complementary