Magnesium deficiency potentiates free radical production associated with myocardial infarction

J Assoc Physicians India. 2000 May;48(5):484-5.


Objective: Oxidative injury and magnesium deficiency may accompany cardiovascular disease states and the study was planned to find out whether magnesium deficiency promotes oxidative injury.

Methods: Serum malonaldehyde (MDA), magnesium, vitamin E and total glutathione levels (GSH) were estimated in 22 patients with acute myocardial infarction and 15 healthy controls.

Results: Low levels of Mg, GSH, vitamin E and elevated levels of MDA were observed in patients of acute myocardial infarction. Statistically significant correlations were observed between Mg and MDA, MDA and GSH, Mg and vitamin E.

Conclusion: Our findings suggest that Mg deficiency can potentiate oxidative injury to post ischaemic myocardium and that antioxidants may have a role in protection against the prooxidant influence(s) of Mg deficiency.

MeSH terms

  • Aged
  • Female
  • Free Radicals
  • Glutathione / blood
  • Humans
  • Magnesium / blood
  • Magnesium Deficiency / blood
  • Magnesium Deficiency / complications*
  • Male
  • Malondialdehyde / blood
  • Middle Aged
  • Myocardial Infarction / blood
  • Myocardial Infarction / etiology*
  • Reactive Oxygen Species / metabolism*
  • Risk Factors
  • Vitamin E / blood


  • Free Radicals
  • Reactive Oxygen Species
  • Vitamin E
  • Malondialdehyde
  • Glutathione
  • Magnesium