MR imaging-guided focused ultrasound surgery of fibroadenomas in the breast: a feasibility study

Radiology. 2001 Apr;219(1):176-85. doi: 10.1148/radiology.219.1.r01ap02176.


Purpose: To test the feasibility of noninvasive magnetic resonance (MR) imaging-guided focused ultrasound surgery (FUS) of benign fibroadenomas in the breast.

Materials and methods: Eleven fibroadenomas in nine patients under local anesthesia were treated with MR imaging-guided FUS. Based on a T2-weighted definition of target volumes, sequential sonications were delivered to treat the entire target. Temperature-sensitive phase-difference-based MR imaging was performed during each sonication to monitor focus localization and tissue temperature changes. After the procedure, T2-weighted and contrast material-enhanced T1-weighted MR imaging were performed to evaluate immediate and long-term effects.

Results: Thermal imaging sequences were improved over the treatment period, with 82% (279 of 342) of the hot spots visible in the last seven treatments. The MR imager was used to measure temperature elevation (12.8 degrees -49.9 degrees C) from these treatments. Eight of the 11 lesions treated demonstrated complete or partial lack of contrast material uptake on posttherapy T1-weighted images. Three lesions showed no marked decrease of contrast material uptake. This lack of effective treatment was most likely due to a lower acoustic power and/or patient movement that caused misregistration. No adverse effects were detected, except for one case of transient edema in the pectoralis muscle 2 days after therapy.

Conclusion: MR imaging-guided FUS can be performed to noninvasively coagulate benign breast fibroadenomas.

Publication types

  • Clinical Trial
  • Clinical Trial, Phase I
  • Clinical Trial, Phase II
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Body Temperature Regulation / physiology
  • Breast Neoplasms / diagnosis
  • Breast Neoplasms / therapy*
  • Equipment Design
  • Feasibility Studies
  • Female
  • Fibroadenoma / diagnosis
  • Fibroadenoma / therapy*
  • Follow-Up Studies
  • Humans
  • Magnetic Resonance Imaging / instrumentation*
  • Prospective Studies
  • Transducers
  • Treatment Outcome
  • Ultrasonic Therapy / instrumentation*