Schedule-dependent effects of haloperidol and amphetamine: multiple-schedule task shows within-subject effects

Pharmacol Biochem Behav. 2001 Jan;68(1):53-63. doi: 10.1016/s0091-3057(00)00431-7.


A two-lever, multiple-schedule task was used to evaluate the effects of haloperidol (HA) and amphetamine (AM) on responding controlled by continuous reinforcement (CRF) and progressive ratio (PR) schedules of reinforcement. Rats were trained to press one lever for food delivered on a CRF schedule and the other lever for food delivered on a PR schedule. The operative schedule was signaled by the illumination of a cuelight mounted above the appropriate lever. Following 30 sessions of training, dose-response functions were determined for HA (0.0075, 0.015, 0.03, and 0.06 mg/kg) and AM (0.0625, 0.125, 0.25, 0.50, 0.75, and 1.00 mg/kg). Both drugs produced dose- and schedule-dependent effects. For example, administration of 0.03 mg/kg HA did not affect responding under the CRF schedule but did reduce responding during PR components, whereas administration of 0.06 mg/kg reduced responding under both schedules of reinforcement. Some doses of AM produced increased responding under the CRF schedule and, within the same session, decreased responding under the PR schedule. The results with HA are consistent with the view that interfering with dopaminergic function affects the allocation and maintenance of responding and that this effect depends on properties of the schedule of reinforcement. The results with AM emphasize that statements about the effects of the drug on positively reinforced behavior cannot be made without reference to specific schedules of reinforcement.

MeSH terms

  • Amphetamine / pharmacology*
  • Animals
  • Antipsychotic Agents / pharmacology*
  • Central Nervous System Stimulants / pharmacology*
  • Conditioning, Operant / drug effects*
  • Data Interpretation, Statistical
  • Dose-Response Relationship, Drug
  • Haloperidol / pharmacology*
  • Male
  • Psychomotor Performance / drug effects
  • Rats
  • Rats, Sprague-Dawley
  • Reinforcement Schedule


  • Antipsychotic Agents
  • Central Nervous System Stimulants
  • Amphetamine
  • Haloperidol