Ginger for nausea and vomiting in pregnancy: randomized, double-masked, placebo-controlled trial

Obstet Gynecol. 2001 Apr;97(4):577-82. doi: 10.1016/s0029-7844(00)01228-x.

Abstract

Objective: To determine the effectiveness of ginger for the treatment of nausea and vomiting of pregnancy.

Methods: Women with nausea and vomiting of pregnancy, who first attended an antenatal clinic at or before 17 weeks' gestation, were invited to participate in the study. During a 5-month period, 70 eligible women gave consent and were randomized in a double-masked design to receive either oral ginger 1 g per day or an identical placebo for 4 days. Subjects graded the severity of their nausea using visual analog scales and recorded the number of vomiting episodes in the previous 24 hours before treatment, and again during 4 consecutive days while taking treatment. At a follow-up visit 7 days later, five-item Likert scales were used to assess the severity of their symptoms.

Results: All participants except three in the placebo group remained in the study. The visual analog scores of posttherapy minus baseline nausea decreased significantly in the ginger group (2.1 +/- 1.9) compared with the placebo group (0.9 +/- 2.2, P =.014). The number of vomiting episodes also decreased significantly in the ginger group (1.4 +/- 1.3) compared with the placebo group (0.3 +/- 1.1, P <.001). Likert scales showed that 28 of 32 in the ginger group had improvement in nausea symptoms compared with 10 of 35 in the placebo group (P <.001). No adverse effect of ginger on pregnancy outcome was detected.

Conclusion: Ginger is effective for relieving the severity of nausea and vomiting of pregnancy.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Administration, Oral
  • Adult
  • Double-Blind Method
  • Drugs, Chinese Herbal / therapeutic use
  • Female
  • Ginger / therapeutic use*
  • Humans
  • Nausea / prevention & control*
  • Pain Measurement
  • Phytotherapy*
  • Plants, Medicinal*
  • Pregnancy
  • Pregnancy Complications / prevention & control*
  • Pregnancy Trimester, First
  • Pregnancy Trimester, Second
  • Treatment Outcome
  • Vomiting / prevention & control*

Substances

  • Drugs, Chinese Herbal