Genetic polymorphisms in cytochrome P450 (CYP) 1A1, CYP1A2, CYP2E1, glutathione S-transferase (GST) M1 and GSTT1 and susceptibility to prostate cancer in the Japanese population

Cancer Lett. 2001 Apr 26;165(2):171-7. doi: 10.1016/s0304-3835(01)00398-6.


Associations between genetic polymorphisms of CYP1A1, CYP1A2, CYP2E1, GSTM1 and GSTT1 and prostate cancer (PCa) were analyzed in a case-control study of 315 individuals. The frequency of valine (Val)/valine (Val) genotypes for CYP1A1 was 11.3% in cases compared with 5.5% in controls, this polymorphism thus being associated with a significantly increased risk of PCa (odds ratio=2.4, 95% confidence interval (CI)=1.01-5.57). No links were detected between PCa and polymorphisms in other enzymes. However, the combination of CYP1A1 (Ile/Val and/or Val/Val) polymorphisms with the GSTM1 null type resulted in an OR of 2.2 (CI=1.10-4.57, 1.12-4.20, respectively). This study suggests that the CYP1A1 polymorphism and its combination with GSTM1 may be associated with PCa susceptibility in the Japanese population.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Case-Control Studies
  • Cytochrome P-450 CYP1A1 / genetics*
  • Cytochrome P-450 CYP1A2 / genetics*
  • Cytochrome P-450 CYP2E1 / genetics*
  • Genetic Predisposition to Disease*
  • Genotype
  • Glutathione Transferase / genetics*
  • Humans
  • Japan
  • Male
  • Odds Ratio
  • Polymorphism, Genetic*
  • Prostatic Neoplasms / genetics*
  • Risk Factors


  • Cytochrome P-450 CYP2E1
  • Cytochrome P-450 CYP1A1
  • Cytochrome P-450 CYP1A2
  • glutathione S-transferase T1
  • Glutathione Transferase
  • glutathione S-transferase M1