[Allergic contact dermatitis to cosmetics containing Melaleuca alternifolia (tea tree oil)]

Ann Dermatol Venereol. 2001 Feb;128(2):123-6.
[Article in French]


Introduction: Melaleuca alternifolia is a coniferous tree found in tropical regions, the needles contain an essential oil that is used in medical and cosmetic products. The essential oil contains turpentines (limonene, alpha-pinene, phellandrene) that are potentially allergenic.

Patients and methods: In 1997, 1216 patients were patch tested in our dermatoligic unit. Fourteen of them tested because of eczema used products containing tea tree oil. The patients used creams, hair products and essential oils containing Melaleuca alternifolia for cosmetic reasons and to treat skin affections. They were patch tested for a standard panel of allergens, topical emulgators, perfumes, plants, topical medications, metal, gloves, topical disinfectants and preservatives, dental products and rubber derivatives. Products containing Melaleuca alternifolia were tested concentrated or diluted.

Results: We report on 7 cases of patients with an allergic contact dermatitis due to tea tree oil. Two of them also exhibited from a delayed type IV hypersensitivity towards fragrance-mix or colophony suggesting the possibility of cross reaction or an allergic group reaction caused by contamination of the colophony with the volatile fraction of turpentines.

Discussion: The allergic potential of low concentrations of Melaleuca alternifolia is presumed to be low on healthy skin. Photoaged Melaleuca alternifolia must be considered to be a stronger sensitizer.

MeSH terms

  • Adult
  • Anti-Infective Agents, Local / adverse effects*
  • Anti-Infective Agents, Local / analysis
  • Bicyclic Monoterpenes
  • Cosmetics / adverse effects*
  • Cosmetics / analysis
  • Cyclohexenes
  • Dermatitis, Allergic Contact / diagnosis*
  • Dermatitis, Allergic Contact / etiology*
  • Female
  • Humans
  • Hypersensitivity, Delayed / chemically induced
  • Hypersensitivity, Delayed / diagnosis
  • Limonene
  • Male
  • Middle Aged
  • Monoterpenes*
  • Patch Tests
  • Resins, Plant / adverse effects
  • Tea Tree Oil / adverse effects*
  • Tea Tree Oil / analysis
  • Terpenes / adverse effects
  • Terpenes / analysis


  • Anti-Infective Agents, Local
  • Bicyclic Monoterpenes
  • Cosmetics
  • Cyclohexenes
  • Monoterpenes
  • Resins, Plant
  • Terpenes
  • Tea Tree Oil
  • rosin
  • Limonene
  • alpha-pinene