Abstract
ICln is a ubiquitously expressed eukaryotic protein. Expression of the protein in Xenopus laevis oocytes, the knocking-down of the protein in fibroblasts, or the reconstitution of the protein in lipid bilayer led to the assumption that this protein is an ionic channel or a significant part thereof. However, other possible roles for ICln in potential regulatory mechanisms have been postulated, as diverse as regulator of cell morphology by interacting with the Skb1 protein and/or interaction with core spliceosomal proteins. Here we show that ICln is able to interact with SnRNP core proteins SmD1, SmD2, SmD3, SmX5 and SmB/B'.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Animals
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Base Sequence
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Gene Library
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Genes, Reporter / genetics
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Humans
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Ion Channels*
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Molecular Sequence Data
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Protein Binding
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Proteins / genetics*
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Proteins / metabolism*
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Recombinant Fusion Proteins / genetics
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Recombinant Fusion Proteins / metabolism*
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Ribonucleoproteins, Small Nuclear / chemistry
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Ribonucleoproteins, Small Nuclear / genetics
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Ribonucleoproteins, Small Nuclear / metabolism*
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Saccharomyces cerevisiae / genetics
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Two-Hybrid System Techniques*
Substances
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CLNS1A protein, human
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Ion Channels
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Lsm2 protein, mouse
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Proteins
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Recombinant Fusion Proteins
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Ribonucleoproteins, Small Nuclear