Effect of tetrapeptide cortagen on regeneration of sciatic nerve

L N Turchaninova; L I Kolosova; V V Malinin; A B Moiseeva; A D Nozdrachev; V K Khavinson

Effect of tetrapeptide cortagen on regeneration of sciatic nerve

Bull Exp Biol Med. 2000 Dec;130(12):1172-4.

Authors

L N Turchaninova¹, L I Kolosova, V V Malinin, A B Moiseeva, A D Nozdrachev, V K Khavinson

Affiliation

¹ Laboratory of General Physiology, I. P. Pavlov Institute of Physiology, Russian Academy of Science; Institute of Bioregulation and Gerontology, North-West Division of the Russian Academy of Medical Sciences, St. Petersburg.

PMID: 11276314

Abstract

Intramuscular injection of 10 microg/kg cortagen to rats during 10 days after transsection and suturing of the sciatic nerve increased the growth rate and conduction velocity in the regenerating nerve fibers by 27% and 40%, respectively.

MeSH terms

Animals
Male
Nerve Regeneration / drug effects*
Neural Conduction / drug effects
Oligopeptides / pharmacology*
Rats
Rats, Wistar
Sciatic Nerve / drug effects
Sciatic Nerve / injuries
Sciatic Nerve / physiology

Substances

Oligopeptides
alanyl-glutamyl-aspartylprolyine