Aryl hydrocarbon hydroxylase induction in rat tissues by naturally occurring indoles of cruciferous plants

J Natl Cancer Inst. 1975 Apr;54(4):985-8.


A phytochemical investigation to identify inducers of increased aryl hydrocarbon hydroxylase (AHH) activity from three cruciferous vegetables, Brussels sprouts, cabbage, and cauliflower, resulted in the identification of indole-3-acetonitrile, indole-3-carbinol, and 3,3'-diindolylmethane as naturally occurring inducers. These compounds are produced during the hydrolysis of indolyl-methyl glucosinolate by the plant enzyme myrosinase.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Aryl Hydrocarbon Hydroxylases / biosynthesis*
  • Dose-Response Relationship, Drug
  • Enzyme Induction*
  • Female
  • Indoles / pharmacology*
  • Intestinal Mucosa / enzymology
  • Liver / enzymology
  • Plants*
  • Rats
  • Vegetables


  • Indoles
  • Aryl Hydrocarbon Hydroxylases