Phosphoinositide 3-kinase signalling pathways

J Cell Sci. 2001 Apr;114(Pt 8):1439-45.

Abstract

Phosphoinositide 3-kinases (PI3Ks) phosphorylate the 3'-OH position of the inositol ring of inositol phospholipids, producing three lipid products: PtdIns(3)P, PtdIns(3,4)P(2) and PtdIns(3,4,5)P(3). These lipids bind to the pleckstrin homology (PH) domains of proteins and control the activity and subcellular localisation of a diverse array of signal transduction molecules. Three major classes of signalling molecule are regulated by binding of D-3 phosphoinositides to PH domains: guanine-nucleotide-exchange proteins for Rho family GTPases, the TEC family tyrosine kinases such as BTK and ITK in B and T lymphocytes, respectively, and the AGC superfamily of serine/threonine protein kinases. These molecules are activated by a variety of extracellular stimuli and have been implicated in a wide range of cellular processes, including cell cycle progression, cell growth, cell motility, cell adhesion and cell survival.

Publication types

  • Review

MeSH terms

  • Animals
  • Carrier Proteins / chemistry
  • Carrier Proteins / metabolism
  • Enzyme Activation
  • Feedback / physiology
  • GTP-Binding Proteins / metabolism*
  • Guanine Nucleotides / chemistry
  • Humans
  • Phosphatidylinositol 3-Kinases / chemistry
  • Phosphatidylinositol 3-Kinases / metabolism*
  • Protein Isoforms / chemistry
  • Protein Isoforms / metabolism
  • Protein-Serine-Threonine Kinases / metabolism*
  • Protein-Tyrosine Kinases / metabolism*
  • Signal Transduction / physiology*

Substances

  • Carrier Proteins
  • Guanine Nucleotides
  • Protein Isoforms
  • Phosphatidylinositol 3-Kinases
  • Protein-Tyrosine Kinases
  • Protein-Serine-Threonine Kinases
  • GTP-Binding Proteins