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. 2001 Apr;7(4):452-8.
doi: 10.1038/86523.

Therapy of Human Tumors in NOD/SCID Mice With Patient-Derived Reactivated Memory T Cells From Bone Marrow

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Therapy of Human Tumors in NOD/SCID Mice With Patient-Derived Reactivated Memory T Cells From Bone Marrow

M Feuerer et al. Nat Med. .

Abstract

In an analysis of 84 primary-operated breast cancer patients and 11 healthy donors, we found that the bone marrow of most patients contained memory T cells with specificity for tumor-associated antigens. Patients' bone marrow and peripheral blood contained CD8+ T cells that specifically bound HLA/peptide tetramers. In short-term culture with autologous dendritic cells pre-pulsed with tumor lysates, patients' memory T cells from bone marrow (but not peripheral blood) could be specifically reactivated to interferon-gamma-producing and cytotoxic effector cells. A single transfer of restimulated bone-marrow T cells into NOD/SCID mice caused regression of autologous tumor xenotransplants associated with infiltration by human T cells and tumor-cell apoptosis and necrosis. T cells from peripheral blood showed much lower anti-tumor reactivity. Our findings reveal an innate, specific recognition of breast cancer antigens and point to a possible novel cancer therapy using patients' bone-marrow-derived memory T cells.

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