mRNA localization: message on the move

Nat Rev Mol Cell Biol. 2001 Apr;2(4):247-56. doi: 10.1038/35067016.

Abstract

Cytoplasmic messenger RNA localization is a key post-transcriptional mechanism of establishing spatially restricted protein synthesis. The characterization of cis-acting signals within localized mRNAs, and the identification of trans-acting factors that recognize these signals, has opened avenues towards identifying the machinery and mechanisms involved in mRNA transport and localization.

Publication types

  • Review

MeSH terms

  • Animals
  • Base Sequence
  • Biological Transport
  • Carrier Proteins / metabolism
  • Cell Nucleus / metabolism
  • Cytoplasm / metabolism
  • Cytoskeleton / metabolism
  • Models, Biological
  • Molecular Motor Proteins / metabolism
  • Neuronal Plasticity
  • RNA, Messenger / chemistry
  • RNA, Messenger / genetics
  • RNA, Messenger / metabolism*
  • Synapses / metabolism

Substances

  • Carrier Proteins
  • Molecular Motor Proteins
  • RNA, Messenger