Cbl: many adaptations to regulate protein tyrosine kinases

Nat Rev Mol Cell Biol. 2001 Apr;2(4):294-307. doi: 10.1038/35067100.

Abstract

Responses to extracellular stimuli are often transduced from cell-surface receptors to protein tyrosine kinases which, when activated, initiate the formation of protein complexes that transmit signals throughout the cell. A prominent component of these complexes is the product of the proto-oncogene c-Cbl, which specifically targets activated protein tyrosine kinases and regulates their signalling. How, then, does this multidomain protein shape the responses generated by these signalling complexes?

Publication types

  • Review

MeSH terms

  • Actins / metabolism
  • Animals
  • Caenorhabditis elegans Proteins*
  • Cytoskeleton / metabolism
  • Down-Regulation
  • Embryonic Induction
  • Helminth Proteins / metabolism
  • Humans
  • Mice
  • Mice, Knockout
  • Models, Molecular
  • Oncogene Protein v-cbl
  • Protein Structure, Tertiary
  • Protein-Tyrosine Kinases / antagonists & inhibitors
  • Protein-Tyrosine Kinases / metabolism*
  • Proto-Oncogene Proteins / chemistry
  • Proto-Oncogene Proteins / deficiency
  • Proto-Oncogene Proteins / genetics
  • Proto-Oncogene Proteins / metabolism*
  • Proto-Oncogene Proteins c-cbl
  • Receptor Protein-Tyrosine Kinases / antagonists & inhibitors
  • Receptor Protein-Tyrosine Kinases / metabolism
  • Retroviridae Proteins, Oncogenic / chemistry
  • Retroviridae Proteins, Oncogenic / deficiency
  • Retroviridae Proteins, Oncogenic / genetics
  • Retroviridae Proteins, Oncogenic / metabolism
  • Signal Transduction
  • T-Lymphocytes / physiology
  • Ubiquitin-Protein Ligases*
  • Ubiquitins / metabolism

Substances

  • Actins
  • Caenorhabditis elegans Proteins
  • Helminth Proteins
  • Oncogene Protein v-cbl
  • Proto-Oncogene Proteins
  • Retroviridae Proteins, Oncogenic
  • Sli-1 protein, C elegans
  • Ubiquitins
  • Proto-Oncogene Proteins c-cbl
  • Ubiquitin-Protein Ligases
  • Protein-Tyrosine Kinases
  • Receptor Protein-Tyrosine Kinases
  • CBL protein, human
  • Cbl protein, mouse