Radiation-induced malignant fibrous histiocytoma of the neck in a patient with laryngeal carcinoma

Am J Otolaryngol. Mar-Apr 2001;22(2):146-9. doi: 10.1053/ajot.2001.22579.


Fibrohistiocytomas are soft tissue tumors of histiocytic origin that have a variety of histological patterns. Although cases of malignant fibrous histiocytoma (MFH) of the head and neck have been reported with increasing frequency in recent years, they are considered rare. We report a case of the giant cell variant of MFH of the neck in which the patient had been given radiotherapy for T1 glottic cancer. Prognosis of MFH, the use of radiation as primary treatment, and its role in the development of secondary primary tumors in the head and neck region are reviewed. [Editorial comment: The authors stress the important relationship between prior radiation therapy and the induction of new tumors.]

Publication types

  • Case Reports

MeSH terms

  • Carcinoma, Squamous Cell / radiotherapy*
  • Head and Neck Neoplasms / etiology*
  • Head and Neck Neoplasms / secondary*
  • Histiocytoma, Benign Fibrous / etiology*
  • Histiocytoma, Benign Fibrous / secondary*
  • Humans
  • Laryngeal Neoplasms / radiotherapy*
  • Male
  • Middle Aged
  • Neoplasms, Radiation-Induced / etiology*
  • Neoplasms, Radiation-Induced / secondary*
  • Neoplasms, Second Primary / diagnosis*
  • Neoplasms, Second Primary / therapy*