Ocular perfusion and age-related macular degeneration

Acta Ophthalmol Scand. 2001 Apr;79(2):108-15. doi: 10.1034/j.1600-0420.2001.079002108.x.


Purpose: To review the role of ocular perfusion in the pathophysiology of age-related macular degeneration (AMD), the leading cause of irreversible blindness in the industrialized world.

Methods: Medline search of the literature published in English or with English abstracts from 1966 to 2000 was performed using various combinations of relevant key words.

Results: Vascular defects have been identified in both nonexudative and exudative AMD patients using fluorescein angiographic methods, laser Doppler flowmetry, indocyanine green angiography, and color Doppler imaging.

Conclusion: Although these studies lend some support to the vascular pathogenesis of AMD, it is not possible to determine if the choroidal perfusion abnormalities play a causative role in nonexudative AMD, if they are simply an association with another primary alteration, such as a primary RPE defect or a genetic defect at the photoreceptor level, or if they are more strongly associated with one particular form of this heterogeneous disease. Further study is warranted.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Blood Flow Velocity
  • Choroid / blood supply
  • Eye / blood supply*
  • Fluorescein Angiography
  • Humans
  • Macular Degeneration / etiology
  • Macular Degeneration / physiopathology*
  • Perfusion
  • Retinal Vessels / physiopathology