doi: 10.1016/0165-1161(75)90064-3.
The effect of methylxanthines on chromosomes of human lyphocytes in culture
- PMID: 1128545
- DOI: 10.1016/0165-1161(75)90064-3
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The effect of methylxanthines on chromosomes of human lyphocytes in culture
Mutat Res.
1975 Feb.
Abstract
The effect of caffeine (I,3,7-trimethylxanthine), theophylline (I,3-dimethylxanthine), theobromine (3,7-dimethylxanthine), paraxanthine (I,7-dimethylxanthine) I-methylxanthine, 3-methylxanthine, and 7-methylxanthine added at the 48th h on the chromosomes of human lymphocytes in 72-h cultures has been investigated. Caffeine and the dimethylxanthines cause breakage at 750 mug/ml, with caffeine the most, and paraxanthine the least clastogenic. I-Methylxanthine and dimethylxanthines with a methyl group in the I-position are the most effective in depressing mitotic indices. No chromosome damage was exhibited by the monomethylxanthines.
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