The purpose of the study was to evaluate the effectiveness of Medical Resonance Therapy Music (MRT-Music) as a psycho-physiological method for the treatment of epilepsy in severe epileptic patients, whose attacks persevered despite comprehensive drug treatments. Under investigation were frequency and severity of epileptic attacks, the subjective state, the dynamics of the inter-paroxysmal symptoms and the individual parameters of the functional asymmetry of the brain (IPFA). Frequency and severity of the paroxysms changed positively in 80 percent of the cases: frequency of attacks were reduced by 75 percent and many attacks manifested in the form of abortive variants. The paroxysmal component, the degree of amnesia and the polymorphism of the attacks were reduced. Such positive changes were 4 times less frequent in the control group. Changes in subjective state were 90 percent positive: the patients felt more healthy, were calmer, had a better mood and fewer ups and downs in mood, released tension, and reduced unrest, wrath, and irritation. The evaluation of the Minnesota Multiphasic Personality Inventory (MMPI) showed clear improvements in the inter-paroxysmal clinical picture, particularly in those parameters that characterise the general degree of sickness, psychasthenic and paranoid traits, hypochondria, aggression and depressive states. Similar positive changes in the control group were observed two times less frequently. The changes of the IPFA-values were positive in 73.3 percent of the patients (27.8 percent in controls), had differently directed shiftings, were dependent on the initial level, and were determined by the location of the epileptic focus.