Atherogenesis and the arginine hypothesis

Curr Atheroscler Rep. 2001 May;3(3):252-9. doi: 10.1007/s11883-001-0068-x.

Abstract

In patients who have elevated levels of plasma ADMA, a relative deficiency of L-arginine has been found to contribute to the pathophysiology of athersclerosis, causing vasoconstriction, and accelerating atherogenesis. This finding--that there is a relative deficiency of L-arginine in atherosclerotic disease--is a breakthrough that will open new avenues of therapy.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Arginine / analogs & derivatives
  • Arginine / antagonists & inhibitors
  • Arginine / blood
  • Arginine / deficiency*
  • Enzyme Inhibitors / blood
  • Humans
  • Nitric Oxide / biosynthesis

Substances

  • Enzyme Inhibitors
  • Nitric Oxide
  • N,N-dimethylarginine
  • Arginine