Itk/Emt: a link between T cell antigen receptor-mediated Ca2+ events and cytoskeletal reorganization

Trends Immunol. 2001 Jan;22(1):17-20. doi: 10.1016/s1471-4906(00)01795-6.


Itk/Emt, a tec family tyrosine kinase, is important for T-cell development and activation through the antigen receptor. Here, we review data suggesting that Itk/Emt is involved in the generation of critical second messengers (Ca(2+), PKC) whose duration it modulates by regulation of cytoskeletal reorganization. We propose that Itk/Emt constitutes an important link between these critical signaling events.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Calcium Signaling*
  • Cytoskeleton / enzymology*
  • Cytoskeleton / immunology*
  • Enzyme Activation / immunology
  • Humans
  • Protein-Tyrosine Kinases / metabolism*
  • Receptors, Antigen, T-Cell / physiology*
  • T-Lymphocytes / enzymology
  • T-Lymphocytes / metabolism


  • Receptors, Antigen, T-Cell
  • Protein-Tyrosine Kinases
  • emt protein-tyrosine kinase