Caspases: more than just killers?

Trends Immunol. 2001 Jan;22(1):31-4. doi: 10.1016/s1471-4906(00)01814-7.


Proteases of the caspase family constitute the central executioners of apoptosis. Several recent observations suggest that caspases and apoptosis-regulatory molecules exert important functions beyond that of cell death, including the control of T-cell proliferation and cell-cycle progression. Here, Los and colleagues propose a model that directly connects cell suicide mechanisms to the regulation of cell-cycle progression.

Publication types

  • Review

MeSH terms

  • Animals
  • Apoptosis / immunology*
  • Caspases / physiology
  • Caspases / toxicity*
  • Humans
  • T-Lymphocytes / cytology
  • T-Lymphocytes / enzymology


  • Caspases