Modulating the immune response with dendritic cells and their growth factors

Trends Immunol. 2001 Jan;22(1):41-7. doi: 10.1016/s1471-4906(00)01794-4.


Different subsets of dendritic cells (DCs) appear to play a role in determining the specific cytokines secreted by T helper (Th) cells. A model is proposed that links together factors such as the pathogen, microenvironment, DCs and T cells in a mechanism that results in a flexible determination of T-cell polarization.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Adjuvants, Immunologic / physiology*
  • Animals
  • Cell Differentiation / immunology
  • Cell Lineage / immunology
  • Dendritic Cells / classification
  • Dendritic Cells / cytology
  • Dendritic Cells / immunology*
  • Growth Substances / immunology*
  • Humans


  • Adjuvants, Immunologic
  • Growth Substances