RANTES: a versatile and controversial chemokine

Trends Immunol. 2001 Feb;22(2):83-7. doi: 10.1016/s1471-4906(00)01812-3.


The activity of the chemokine RANTES is not restricted merely to chemotaxis. It is a powerful leukocyte activator, a feature potentially relevant in a range of inflammatory disorders. RANTES has attracted attention because it can potently suppress and, in some circumstances, enhance HIV replication. These characteristics are critically dependent on its ability to self-aggregate and bind to glycosaminoglycans.

Publication types

  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Chemokine CCL5 / physiology*
  • Chemokines / physiology*
  • Humans
  • Inflammation / immunology
  • Models, Molecular
  • Molecular Sequence Data


  • Chemokine CCL5
  • Chemokines