The role of molecules that mediate apoptosis in T-cell selection

Trends Immunol. 2001 Feb;22(2):107-11. doi: 10.1016/s1471-4906(00)01797-x.


The T-cell repertoire is generated as a result of selection processes that happen in the thymus. The molecular basis of these processes is beginning to be elucidated and many of the molecules identified have a role in regulating cell death. These molecules range from orphan nuclear receptors and transcription factors to cyclin-dependent kinase 2 and Bcl2 family members.

Publication types

  • Review

MeSH terms

  • Animals
  • Apoptosis / immunology*
  • Clonal Deletion
  • DNA-Binding Proteins / physiology*
  • T-Lymphocytes / cytology*
  • T-Lymphocytes / immunology*
  • Transcription Factors / physiology*


  • DNA-Binding Proteins
  • Transcription Factors