Net, an Ets ternary complex transcription factor, is expressed in sites of vasculogenesis, angiogenesis, and chondrogenesis during mouse development

Mech Dev. 2001 Apr;102(1-2):205-8. doi: 10.1016/s0925-4773(01)00289-1.


The Net gene encodes an Ets transcription factor belonging to the ternary complex factor subfamily. We studied Net expression during mouse development (E7.5-E18.5) by in situ hybridization. Net is expressed at E7.5-8.5 in developing vascular primordia, including the allantoic vessels, heart endocardium and dorsal aortae. Vascular endothelial cell expression persists throughout development. Additional sites of expression appear at E9.5-E10.5, especially in facial, branchial arch and distal limb-bud mesenchyme. Later, expression is most conspicuous in developing cartilage and becomes progressively restricted to perichondrium. Net expression during mouse development correlates with vasculogenesis, angiogenesis and cartilage ontogeny.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Brain / metabolism
  • Cartilage / embryology
  • Chondrogenesis*
  • Embryo, Mammalian / metabolism
  • Endothelium, Vascular / cytology
  • Endothelium, Vascular / metabolism
  • In Situ Hybridization
  • Mesoderm / metabolism
  • Mice
  • Neovascularization, Physiologic*
  • Oncogene Proteins*
  • Proto-Oncogene Proteins / chemistry
  • Proto-Oncogene Proteins c-ets
  • RNA, Messenger / metabolism
  • Time Factors
  • Transcription Factors / biosynthesis*
  • Transcription Factors / chemistry


  • Elk3 protein, mouse
  • Oncogene Proteins
  • Proto-Oncogene Proteins
  • Proto-Oncogene Proteins c-ets
  • RNA, Messenger
  • Transcription Factors