Expression of the Na-K-2Cl-cotransporter NKCC1 during mouse development

Mech Dev. 2001 Apr;102(1-2):267-9. doi: 10.1016/s0925-4773(01)00309-4.


Here we describe the expression pattern of the Na-K-2Cl-cotransporter NKKC1 during embryonal and early postnatal mouse development. During early stages hybridization signals were detected over single cells of the developing neuroepithelia, whereas the neuroepithelium of the basal telencephalon was labeled continuously. With ongoing differentiation a distinct pattern of hybridization became apparent, which switched from a neuronal to a more glial pattern in the adult. Outside the nervous system NKCC1 transcripts were present in many organs and were mostly confined to epithelia.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Biological Transport
  • Carrier Proteins / biosynthesis*
  • Central Nervous System / embryology
  • Central Nervous System / metabolism
  • Chlorine / metabolism*
  • DNA, Complementary / metabolism
  • In Situ Hybridization
  • Mice
  • Neuroglia / metabolism
  • Potassium / metabolism*
  • RNA, Messenger / metabolism
  • Sodium / metabolism*
  • Sodium-Potassium-Chloride Symporters
  • Tissue Distribution


  • Carrier Proteins
  • DNA, Complementary
  • RNA, Messenger
  • Sodium-Potassium-Chloride Symporters
  • Chlorine
  • Sodium
  • Potassium