Viral suppressors of RNA silencing

Curr Opin Biotechnol. 2001 Apr;12(2):150-4. doi: 10.1016/s0958-1669(00)00190-7.


The suppression of RNA silencing by plant viruses represents a viral adaptation to a novel host antiviral defense. Three types of viral suppressors have been identified through the use of a variety of silencing suppression assays. The first two types of suppressor are capable of a complete or partial reversal of pre-existing RNA silencing; the third type does not reverse RNA silencing but can instead prevent its systemic signaling.

Publication types

  • Review

MeSH terms

  • Cysteine Endopeptidases / pharmacology*
  • Gene Silencing / drug effects*
  • Genes, Suppressor / physiology
  • Plant Viral Movement Proteins
  • Plant Viruses / chemistry*
  • RNA, Plant / drug effects*
  • RNA, Plant / genetics
  • Viral Proteins / pharmacology*


  • Plant Viral Movement Proteins
  • RNA, Plant
  • Viral Proteins
  • Cysteine Endopeptidases
  • HC-Pro protein, potyvirus