Assessment of left ventricular function by real-time 3-dimensional echocardiography compared with conventional noninvasive methods

J Am Soc Echocardiogr. 2001 Apr;14(4):275-84. doi: 10.1067/mje.2001.111158.


Quantitative assessment of left ventricular ejection fraction is an essential component of cardiac evaluation. We performed real-time 3-dimensional echocardiography in 56 consecutive patients who underwent multigated radionuclide angiography. Thirteen patients were excluded for the following reasons: 5 for large size of left ventricle required for image acquisition, 5 for suboptimal image quality in real-time 3-dimensional echocardiography, and 3 for atrial fibrillation. Finally, we compared left ventricular ejection fraction assessed by real-time 3-dimensional echocardiography and conventional 2-dimensional echocardiography with that obtained by multigated radionuclide angiography in 43 patients. Left ventricular ejection fraction was determined by real-time 3-dimensional echocardiography with the use of parallel plane-disks and sector plane-disks summation methods. A good correlation was obtained between both real-time 3-dimensional echocardiography methods and multigated radionuclide angiography (r = 0.87 and 0.90, standard error of estimate = 3.7% and 4.2%), whereas the relation between the 2-dimensional echocardiography method and radionuclide angiography demonstrated a significant departure from the line of identity (P <.001). In addition, interobserver variability was significantly lower (P <.05) for the real-time 3-dimensional echocardiography methods than that by the 2-dimensional echocardiography method. Real-time 3-dimensional echocardiography may be used for quantification of left ventricular function as an alternative to conventional methods in patients with adequate image quality.

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Aged
  • Coronary Angiography
  • Echocardiography
  • Echocardiography, Three-Dimensional*
  • Female
  • Humans
  • Linear Models
  • Male
  • Middle Aged
  • Observer Variation
  • Phantoms, Imaging
  • Radionuclide Angiography
  • Ventricular Dysfunction, Left / diagnostic imaging*