Renal failure and vestibular toxicity in an adolescent with cystic fibrosis receiving gentamicin and standard-dose ibuprofen

Pediatr Pulmonol. 2001 Apr;31(4):314-6. doi: 10.1002/ppul.1047.


Gentamicin and standard-dose ibuprofen were administered to an adolescent with cystic fibrosis who developed renal failure and severe vestibulotoxicity. A contributing factor was possible suboptimal intravascular volume status. Because of the potential severity of this drug interaction, hydration status and renal and vestibular functions should be closely monitored in patients receiving ibuprofen and intravenous aminoglycosides concomitantly.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Anti-Bacterial Agents / adverse effects*
  • Anti-Inflammatory Agents, Non-Steroidal / adverse effects*
  • Cystic Fibrosis / drug therapy*
  • Gentamicins / adverse effects*
  • Humans
  • Ibuprofen / adverse effects*
  • Male
  • Renal Insufficiency / chemically induced*
  • Vestibular Diseases / chemically induced*
  • Water-Electrolyte Balance


  • Anti-Bacterial Agents
  • Anti-Inflammatory Agents, Non-Steroidal
  • Gentamicins
  • Ibuprofen