Abstract
The C. elegans gon-2 gene is required for the post-embryonic mitotic cell divisions of the gonadal precursor cells. A single major transcript of approximately 6.7 kb is derived from the gon-2 locus. This mRNA encodes a protein related to the TRP family of cation channels and has a high degree of similarity to several vertebrate genes, including melastatin. Mutant alleles of gon-2 affect evolutionarily conserved amino acid residues. Northern analyses suggest that gon-2 expression is not limited to gonadal tissues.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Alleles
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Amino Acid Sequence
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Animals
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Caenorhabditis elegans / genetics*
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Caenorhabditis elegans / physiology
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Calcium Channels / genetics*
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Calcium Channels / physiology
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Cell Cycle / genetics
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Cell Cycle / physiology*
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Cell Division / physiology
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Conserved Sequence / genetics
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Genes, Helminth / genetics*
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Gonads / cytology
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Gonads / growth & development
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Molecular Sequence Data
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Mutation
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RNA, Messenger / genetics
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RNA, Messenger / metabolism
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Sequence Alignment
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Sequence Homology, Amino Acid
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TRPC Cation Channels
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Transcription, Genetic
Substances
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Calcium Channels
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RNA, Messenger
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TRPC Cation Channels
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transient receptor potential cation channel, subfamily C, member 1