The C. elegans gon-2 gene encodes a putative TRP cation channel protein required for mitotic cell cycle progression

Gene. 2001 Mar 21;266(1-2):103-10. doi: 10.1016/s0378-1119(01)00373-0.


The C. elegans gon-2 gene is required for the post-embryonic mitotic cell divisions of the gonadal precursor cells. A single major transcript of approximately 6.7 kb is derived from the gon-2 locus. This mRNA encodes a protein related to the TRP family of cation channels and has a high degree of similarity to several vertebrate genes, including melastatin. Mutant alleles of gon-2 affect evolutionarily conserved amino acid residues. Northern analyses suggest that gon-2 expression is not limited to gonadal tissues.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Alleles
  • Amino Acid Sequence
  • Animals
  • Caenorhabditis elegans / genetics*
  • Caenorhabditis elegans / physiology
  • Calcium Channels / genetics*
  • Calcium Channels / physiology
  • Cell Cycle / genetics
  • Cell Cycle / physiology*
  • Cell Division / physiology
  • Conserved Sequence / genetics
  • Genes, Helminth / genetics*
  • Gonads / cytology
  • Gonads / growth & development
  • Molecular Sequence Data
  • Mutation
  • RNA, Messenger / genetics
  • RNA, Messenger / metabolism
  • Sequence Alignment
  • Sequence Homology, Amino Acid
  • TRPC Cation Channels
  • Transcription, Genetic


  • Calcium Channels
  • RNA, Messenger
  • TRPC Cation Channels
  • transient receptor potential cation channel, subfamily C, member 1