The Molecular Biology of Hepatitis C Virus. Genotypes and Quasispecies

Clin Liver Dis. 1999 Nov;3(4):693-716, vii. doi: 10.1016/s1089-3261(05)70234-8.


Hepatitis C virus (HCV) is an important cause of chronic liver disease worldwide. HCV is a positive-strand genotype RNA virus with extensive genetic heterogeneity; HCV isolates define 6 major genotypes, and HCV circulates within an infected individual as a number of closely related but distinct species, termed a quasispecies. This article reviews characteristic aspects of HCV molecular biology and their implications for treatment and vaccine development.

Publication types

  • Review

MeSH terms

  • 3' Untranslated Regions / physiology
  • Genetic Variation
  • Genome, Viral
  • Genotype
  • Hepacivirus / genetics*
  • Hepatitis C / drug therapy
  • Hepatitis C / virology
  • Viral Nonstructural Proteins / physiology
  • Viral Structural Proteins / physiology
  • Viral Vaccines / immunology


  • 3' Untranslated Regions
  • Viral Nonstructural Proteins
  • Viral Structural Proteins
  • Viral Vaccines