Toxic effect of troglitazone on cultured rat hepatocytes

Life Sci. 2001 Mar 9;68(16):1867-76. doi: 10.1016/s0024-3205(01)00985-7.

Abstract

We examined the cytotoxicity of troglitazone toward cultured rat hepatocytes. The drug concentration- and time-dependently decreased cell viability and increased lactate dehydrogenase leakage from the cells. Troglitazone-induced cell death was characterized by "DNA ladders", condensation of nuclei, and a positive reaction to in situ nick-end labeling. The results indicate that troglitazone can cause apoptotic cell death in cultured rat hepatocytes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Nucleus / drug effects
  • Cell Nucleus / pathology
  • Cell Survival / drug effects
  • Cells, Cultured
  • Chromans / toxicity*
  • DNA Fragmentation / drug effects
  • Dose-Response Relationship, Drug
  • Hepatocytes / drug effects*
  • Hypoglycemic Agents / toxicity*
  • In Situ Nick-End Labeling
  • Male
  • Rats
  • Rats, Wistar
  • Thiazoles / toxicity*
  • Thiazolidinediones*
  • Troglitazone

Substances

  • Chromans
  • Hypoglycemic Agents
  • Thiazoles
  • Thiazolidinediones
  • Troglitazone