LY294002-geldanamycin Heterodimers as Selective Inhibitors of the PI3K and PI3K-related Family

Bioorg Med Chem Lett. 2001 Apr 9;11(7):909-13. doi: 10.1016/s0960-894x(01)00099-3.

Abstract

Several LY294002-GM heterodimers were synthesized with the intent of modulating their activity in the presence of hsp90 and thereby creating selective inhibitors of PI3K and PI3K-related family.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Ataxia Telangiectasia Mutated Proteins
  • Benzoquinones
  • Cell Cycle Proteins
  • Chromones / chemistry
  • Chromones / pharmacology*
  • DNA-Activated Protein Kinase
  • DNA-Binding Proteins*
  • Dimerization
  • HSP90 Heat-Shock Proteins / chemistry
  • HSP90 Heat-Shock Proteins / metabolism
  • Inhibitory Concentration 50
  • Lactams, Macrocyclic
  • Morpholines / chemistry
  • Morpholines / pharmacology*
  • Phosphoinositide-3 Kinase Inhibitors*
  • Protein-Serine-Threonine Kinases / antagonists & inhibitors*
  • Protein-Serine-Threonine Kinases / chemistry
  • Protein-Serine-Threonine Kinases / metabolism
  • Quinones / chemistry
  • Quinones / pharmacology*
  • Tumor Suppressor Proteins

Substances

  • Benzoquinones
  • Cell Cycle Proteins
  • Chromones
  • DNA-Binding Proteins
  • HSP90 Heat-Shock Proteins
  • Lactams, Macrocyclic
  • Morpholines
  • Phosphoinositide-3 Kinase Inhibitors
  • Quinones
  • Tumor Suppressor Proteins
  • 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one
  • Ataxia Telangiectasia Mutated Proteins
  • DNA-Activated Protein Kinase
  • Protein-Serine-Threonine Kinases
  • geldanamycin