Cloning and characterization of TNKL, a member of tankyrase gene family

Genes Immun. 2001 Feb;2(1):52-5. doi: 10.1038/sj.gene.6363722.


By serological screening of a breast tumor cDNA library we have identified a novel human gene, tnkl, encoding an ankyrin-related protein with a high degree of similarity to tankyrase, the poly(ADP-ribose)polymerase associated with human telomeres (Smith et al, Science 282: 1484). The tnkl gene maps to chromosome 10, while the tnks gene encoding tankyrase is located on chromosome 8. The predicted 1166-aa protein product of the tnkl gene is 78% identical to human tankyrase and 62% to a putative D. melanogaster protein. Since the proteins have essentially identical domain structures, the corresponding genes form a distinct gene family. The possible link between TNKL and cancer justifies its further functional analysis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Cloning, Molecular
  • DNA Primers
  • DNA, Complementary
  • Humans
  • Molecular Sequence Data
  • Poly(ADP-ribose) Polymerases / chemistry
  • Poly(ADP-ribose) Polymerases / genetics*
  • Sequence Homology, Amino Acid
  • Tankyrases*


  • DNA Primers
  • DNA, Complementary
  • Poly(ADP-ribose) Polymerases
  • Tankyrases
  • TNKS protein, human

Associated data

  • GENBANK/AF264912