Hemodynamic and hormonal effects of human ghrelin in healthy volunteers

Am J Physiol Regul Integr Comp Physiol. 2001 May;280(5):R1483-7. doi: 10.1152/ajpregu.2001.280.5.R1483.

Abstract

To investigate hemodynamic and hormonal effects of ghrelin, a novel growth hormone (GH)-releasing peptide, we gave six healthy men an intravenous bolus of human ghrelin (10 microg/kg) or placebo and vice versa 1-2 wk apart in a randomized fashion. Ghrelin elicited a marked increase in circulating GH (15-fold). The elevation of GH lasted longer than 60 min after the bolus injection. Injection of ghrelin significantly decreased mean arterial pressure (-12 mmHg, P < 0.05) without a significant change in heart rate (-4 beats/min, P = 0.39). Ghrelin significantly increased cardiac index (+16%, P < 0.05) and stroke volume index (+22%, P < 0.05). We also examined ghrelin receptor [GH secretagogues receptor (GHS-R)] gene expression in the aortas, the left ventricles, and the left atria of rats by RT-PCR. GHS-R mRNA was detectable in the rat aortas, left ventricles, and left atria, suggesting that ghrelin may cause cardiovascular effects through GH-independent mechanisms. In summary, human ghrelin elicited a potent, long-lasting GH release and had beneficial hemodynamic effects via reducing cardiac afterload and increasing cardiac output without an increase in heart rate.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Animals
  • Aorta, Thoracic / metabolism
  • Blood Pressure / drug effects
  • Cyclic AMP / blood
  • Cyclic GMP / blood
  • Epinephrine / blood
  • Ghrelin
  • Heart Atria
  • Heart Ventricles
  • Hemodynamics / drug effects
  • Hemodynamics / physiology*
  • Hormones / blood*
  • Hormones / metabolism
  • Human Growth Hormone / physiology
  • Humans
  • Injections, Intravenous
  • Insulin-Like Growth Factor I / metabolism
  • Male
  • Myocardium / metabolism
  • Norepinephrine / blood
  • Peptide Hormones*
  • Peptides / administration & dosage
  • Peptides / pharmacology*
  • Pituitary Hormones / blood
  • Placebos
  • RNA, Messenger / analysis
  • Rats
  • Rats, Wistar
  • Receptors, Cell Surface / genetics*
  • Receptors, G-Protein-Coupled*
  • Receptors, Ghrelin
  • Reverse Transcriptase Polymerase Chain Reaction
  • Transcription, Genetic

Substances

  • Ghrelin
  • Hormones
  • Peptide Hormones
  • Peptides
  • Pituitary Hormones
  • Placebos
  • RNA, Messenger
  • Receptors, Cell Surface
  • Receptors, G-Protein-Coupled
  • Receptors, Ghrelin
  • Human Growth Hormone
  • Insulin-Like Growth Factor I
  • Cyclic AMP
  • Cyclic GMP
  • Norepinephrine
  • Epinephrine