Transcription factors: bound to activate or repress

Trends Biochem Sci. 2001 Apr;26(4):211-3. doi: 10.1016/s0968-0004(01)01812-6.


The complex processes of eukaryotic gene expression are controlled by a relatively small number of transcription factors whose activities are modulated by a diverse set of regulatory mechanisms. A recent paper describes the molecular basis for one such mechanism in which the Pit-1 transcription factor activates or represses transcription depending on the sequence of the DNA to which it binds. The mechanism by which the binding-site sequence regulates the activity of Pit-1 is discussed in relation to that of other transcription factors.

Publication types

  • News

MeSH terms

  • Binding Sites
  • DNA / metabolism
  • Gene Expression Regulation / physiology*
  • Transcription Factors / metabolism
  • Transcription Factors / physiology*


  • Transcription Factors
  • DNA