Attenuation of infarct size in rats and dogs after myocardial infarction by low-energy laser irradiation

Lasers Surg Med. 2001;28(3):204-11. doi: 10.1002/lsm.1039.


Background and objective: The aim of the present study was to investigate the possibility that low-energy laser irradiation attenuates infarct size formation after induction of chronic myocardial infarction (MI) in small and large experimental animals.

Study design/materials and methods: Laser irradiation was applied to the infarcted area of rats and dogs at various power densities (2.5 to 20 mW/cm(2)) after occlusion of the coronary artery.

Results: In infarcted laser-irradiated rats that received laser irradiation immediately and 3 days after MI at energy densities of 2.5, 6, and 20 mW/cm(2), there was a 14%, 62% (significant; P < 0.05), and 2.8% reduction of infarct size (14 days after MI) relative to non--laser-irradiated rats, respectively. In dogs, a 49% (significant; P < 0.01) reduction of infarct size was achieved.

Conclusion: The results of the present study indicate that delivery of low-energy laser irradiation to infarcted myocardium in rats and dogs has a profound effect on the infarct size after MI.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Disease Models, Animal
  • Dogs
  • Female
  • Immunohistochemistry
  • Laser Therapy / methods*
  • Male
  • Myocardial Infarction / pathology*
  • Myocardial Infarction / surgery*
  • Probability
  • Rats
  • Rats, Sprague-Dawley
  • Reference Values
  • Sensitivity and Specificity