[Electrical properties of intact rabbit aortic endothelium]

Fiziol Zh. 2001;47(1):9-16.
[Article in Ukrainian]

Abstract

The ionic nature of membrane potential and electrical reactions to vasodilators and vasoconstrictors of intact endothelium of rabbit aorta have been investigated. It has been shown that K+ and Na+, but not Cl- permeability form membrane resting potential. The endothelium was hyperpolarized by ACh. ATP produced the triphasic reaction of short small depolarization, hyperpolarization followed by depolarization. Both noradrenalin and serotonin evoked depolarization.

Publication types

  • Comparative Study
  • English Abstract

MeSH terms

  • Acetylcholine / pharmacology
  • Adenosine Triphosphate / pharmacology
  • Animals
  • Aorta, Thoracic / cytology
  • Electrolytes / pharmacology
  • Endothelium, Vascular / cytology
  • Endothelium, Vascular / drug effects
  • Endothelium, Vascular / physiology*
  • In Vitro Techniques
  • Male
  • Membrane Potentials / drug effects
  • Membrane Potentials / physiology
  • Norepinephrine / pharmacology
  • Rabbits
  • Serotonin / pharmacology
  • Vasoconstrictor Agents / pharmacology
  • Vasodilator Agents / pharmacology

Substances

  • Electrolytes
  • Vasoconstrictor Agents
  • Vasodilator Agents
  • Serotonin
  • Adenosine Triphosphate
  • Acetylcholine
  • Norepinephrine