Intravitreal triamcinolone for uveitic cystoid macular edema: an optical coherence tomography study

Ophthalmology. 2001 Apr;108(4):765-72. doi: 10.1016/s0161-6420(00)00658-8.


Purpose: To investigate the use of intravitreal injection of triamcinolone acetonide (TA) for the treatment of refractory uveitic cystoid macular edema (CME).

Design: Prospective, nonrandomized, self-controlled comparative trial.

Participants: Six patients with chronic CME resistant to treatment with systemic steroids, orbital floor steroids, and cyclosporine A. Three patients were followed for more than 1 year, and the other three for between 3 and 9 months.

Intervention: Injection of 2 mg of TA into the vitreous cavity.

Testing: Optical coherence tomography scanning of the fovea before and after injection and logarithmic minimal angle of resolution visual acuity.

Main outcome measures: Visual acuity, retinal thickness, cystoid space height, and intraocular pressure.

Results: There was complete anatomic resolution of CME in five of the six cases within 1 week after injection. Cystoid spaces began to return between 6 weeks and 3 months after injection. Two patients with longer term follow-up responded to further orbital floor steroid injection and had no CME 1 year later. One patient had raised intraocular pressure develop, requiring a trabeculectomy. Mean improvement in visual acuity after 12 months was 0.27 (range, 0.14-0.42).

Conclusions: Complete anatomic and, to some extent, functional recovery can be induced by intravitreal TA despite long-term refractory inflammatory CME. Optical coherence tomography aids in the management of these cases.

Publication types

  • Case Reports
  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Diagnostic Techniques, Ophthalmological*
  • Female
  • Glucocorticoids / therapeutic use*
  • Humans
  • Injections
  • Interferometry
  • Intraocular Pressure
  • Macular Edema / diagnosis
  • Macular Edema / drug therapy*
  • Macular Edema / etiology
  • Male
  • Middle Aged
  • Prospective Studies
  • Sound
  • Tomography
  • Treatment Outcome
  • Triamcinolone Acetonide / therapeutic use*
  • Uveitis / complications
  • Uveitis / diagnosis
  • Uveitis / drug therapy*
  • Visual Acuity
  • Vitreous Body / drug effects*


  • Glucocorticoids
  • Triamcinolone Acetonide