Plasminogen-activator-inhibitor-1 4G/5G promoter polymorphism and prognosis of severely injured patients

Lancet. 2001 Apr 7;357(9262):1096-7. doi: 10.1016/S0140-6736(00)04311-7.

Abstract

A single base pair insertion/deletion (4G/SG) promoter polymorphism in the plasminogen-activator-inhibitor-1 (PAI-1) gene is thought to play a part in prognosis after severe trauma. We investigated the relation between outcome of severe trauma, PAI-1 concentrations, and PAP-1 genotype in 61 patients who had been severely injured. 11 (58%) of 19 patients with genotype 4G/4G did not survive, whereas only eight (28%) of 29 patients with heterozygous genotype 4G/SG, and two (15%) of 13 patients with genotype 5G/5G died. The PAI-1 4G allele is associated with high concentrations of PAI-1 in plasma and a poor survival rate after severe trauma.

Publication types

  • Letter

MeSH terms

  • Alleles
  • Genotype
  • Heterozygote
  • Humans
  • Interleukin-1 / blood
  • Multiple Organ Failure / genetics
  • Multiple Organ Failure / mortality
  • Pancreatitis-Associated Proteins
  • Plasminogen Activator Inhibitor 1 / blood
  • Plasminogen Activator Inhibitor 1 / genetics*
  • Point Mutation
  • Polymorphism, Genetic*
  • Prognosis
  • Promoter Regions, Genetic / genetics*
  • Risk Factors
  • Sepsis / genetics
  • Sepsis / mortality
  • Tumor Necrosis Factor-alpha / analysis
  • Wounds and Injuries / blood
  • Wounds and Injuries / genetics
  • Wounds and Injuries / mortality*

Substances

  • Interleukin-1
  • Pancreatitis-Associated Proteins
  • Plasminogen Activator Inhibitor 1
  • REG3A protein, human
  • Tumor Necrosis Factor-alpha