IL-17 derived from juxta-articular bone and synovium contributes to joint degradation in rheumatoid arthritis

Arthritis Res. 2001;3(3):168-77. doi: 10.1186/ar294. Epub 2001 Jan 26.


The origin and role of IL-17, a T-cell derived cytokine, in cartilage and bone destruction during rheumatoid arthritis (RA) remain to be clarified. In human ex vivo models, addition of IL-17 enhanced IL-6 production and collagen destruction, and inhibited collagen synthesis by RA synovium explants. On mouse cartilage, IL-17 enhanced cartilage proteoglycan loss and inhibited its synthesis. On human RA bone explants, IL-17 also increased bone resorption and decreased formation. Addition of IL-1 in these conditions increased the effect of IL-17. Blocking of bone-derived endogenous IL-17 with specific inhibitors resulted in a protective inhibition of bone destruction. Conversely, intra-articular administration of IL-17 into a normal mouse joint induced cartilage degradation. In conclusion, the contribution of IL-17 derived from synovium and bone marrow T cells to joint destruction suggests the control of IL-17 for the treatment of RA.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antibodies, Blocking / pharmacology
  • Antibodies, Monoclonal / pharmacology
  • Arthritis, Rheumatoid / metabolism*
  • Bone and Bones / drug effects*
  • Bone and Bones / metabolism
  • Cartilage, Articular / drug effects
  • Cartilage, Articular / metabolism
  • Cartilage, Articular / pathology
  • Chondrocytes / drug effects
  • Chondrocytes / metabolism
  • Collagen / metabolism
  • Drug Combinations
  • Injections, Intra-Articular
  • Insulin-Like Growth Factor I / pharmacology
  • Interleukin-1 / pharmacology
  • Interleukin-17 / administration & dosage
  • Interleukin-17 / immunology
  • Interleukin-17 / pharmacology*
  • Interleukin-6 / biosynthesis
  • Knee Joint / drug effects
  • Knee Joint / metabolism
  • Knee Joint / pathology
  • Mice
  • Mice, Inbred C57BL
  • Proteoglycans / biosynthesis
  • Synovial Membrane / drug effects*
  • Synovial Membrane / metabolism


  • Antibodies, Blocking
  • Antibodies, Monoclonal
  • Drug Combinations
  • Interleukin-1
  • Interleukin-17
  • Interleukin-6
  • Proteoglycans
  • Insulin-Like Growth Factor I
  • Collagen