[Multiple sclerosis: clinical and laboratorial correlation]

Arq Neuropsiquiatr. 2001 Mar;59(1):89-91. doi: 10.1590/s0004-282x2001000100018.
[Article in French]

Abstract

The clinical and demographic characteristics of 86 Brazilian patients with clinically definite multiple sclerosis (MS) were compared to the cerebrospinal fluid (CSF) findings. The disease course was relapsing-remitting in 71% and chronic progressive in 29% of the cases. The IgG index was increased in 76% in the chronic progressive status and 46% and 49% during the bout and remission, respectively (p < 0.005). Only 36% of the MS patients using corticosteroids had increased IgG index, in comparison to the 64% of the patients without immunosupressive treatment. Oligoclonal IgG bands were detected in the CSF of 77% and 88% of the MS corticosteroids users and non-users, respectively. The quantitative study of intrathecal synthesis of IgG contributes to demonstrate the immunological differences between the two forms of MS, the relapsing-remitting and the chronic progressive. The treatment with corticosteroids decreases quantitatively the intrathecal synthesis of IgG but not the presence of oligoclonal bands.

Publication types

  • English Abstract

MeSH terms

  • Adolescent
  • Adult
  • Child
  • Female
  • Humans
  • Immunoglobulin G / cerebrospinal fluid*
  • Isoelectric Focusing
  • Male
  • Middle Aged
  • Multiple Sclerosis / blood
  • Multiple Sclerosis / cerebrospinal fluid*
  • Multiple Sclerosis / drug therapy
  • Statistics, Nonparametric

Substances

  • Immunoglobulin G