Automated synthesis and purification of [18F]bromofluoromethane at high specific radioactivity

Appl Radiat Isot. 2001 Jun;54(6):927-33. doi: 10.1016/s0969-8043(00)00358-4.


[18F]Bromofluoromethane was synthesised from dibromomethane by substitution of bromine with [18F]fluoride. The synthesis and separation of the [18F]bromofluoromethane were automated. [18F]Bromofluoromethane was used to convert a phenolic and a thiophenolic precursor into a labelled ether and thioether, respectively. The specific radioactivity of these labelled products was determined with both high-performance liquid chromatography (with UV-absorbance detection) and liquid chromatography (with mass spectrometric detection). The median for the specific radioactivity, corrected at the end of radionuclide production, was 934GBq/micromol (range 40-9900 GBq/micromol; n = 83).

MeSH terms

  • Automation / instrumentation
  • Automation / methods
  • Chromatography, High Pressure Liquid
  • Cyclotrons
  • Fluorine Radioisotopes*
  • Hydrocarbons, Brominated / chemical synthesis*
  • Hydrocarbons, Fluorinated / chemical synthesis*
  • Indicators and Reagents
  • Mass Spectrometry


  • Fluorine Radioisotopes
  • Hydrocarbons, Brominated
  • Hydrocarbons, Fluorinated
  • Indicators and Reagents
  • bromofluoromethane