Challenges and controversies in immunization safety

Infect Dis Clin North Am. 2001 Mar;15(1):21-39, viii. doi: 10.1016/s0891-5520(05)70266-x.


No vaccine is perfectly safe or effective. As diseases such as diphtheria and polio fade, vaccine safety concerns, especially alleged links between vaccinations and several chronic illnesses, have become increasingly prominent in the media and to the public. This article reviews the current scientific evidence on several recent vaccine safety controversies. It also provides information on how various safety research is conducted, some of the concurrent challenges, and finally, some guidance on communicating with patients on vaccine risks.

Publication types

  • Review

MeSH terms

  • Autistic Disorder / etiology
  • Autoimmune Diseases / etiology
  • Data Collection
  • Guillain-Barre Syndrome / etiology
  • Humans
  • Immunization*
  • Intussusception / etiology
  • Risk Assessment
  • Safety*
  • Vaccines* / administration & dosage
  • Vaccines* / adverse effects
  • Vaccines, Combined


  • Vaccines
  • Vaccines, Combined