Piperine inhibits gastric emptying and gastrointestinal transit in rats and mice

Planta Med. 2001 Mar;67(2):176-9. doi: 10.1055/s-2001-11505.


Piperine (1), an alkaloid of black and long peppers, inhibited gastric emptying (GE) of solids/liquids in rats and gastrointestinal transit (GT) in mice in a dose and time dependent manner. Compound 1 significantly inhibited GE of solids and GT at the doses extrapolated from humans (1 mg/kg and 1.3 mg/kg p.o. in rats and mice, respectively). However, at the same dose the effect was insignificant for GE of liquids. One week oral treatment of 1 mg/kg and 1.3 mg/kg in rats and mice, respectively, did not produce a significant change in activity as compared to single dose administration. GE inhibitory activity of 1 is independent of gastric acid and pepsin secretion.

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkaloids*
  • Animals
  • Benzodioxoles
  • Digestive System / drug effects*
  • Dose-Response Relationship, Drug
  • Gastric Emptying / drug effects*
  • Male
  • Mice
  • Molecular Structure
  • Piperidines / toxicity*
  • Plant Extracts / toxicity
  • Plants, Medicinal / chemistry
  • Polyunsaturated Alkamides
  • Rats


  • Alkaloids
  • Benzodioxoles
  • Piperidines
  • Plant Extracts
  • Polyunsaturated Alkamides
  • oleoresins
  • piperine