Sarco(endo)plasmic reticulum calcium pumps: recent advances in our understanding of structure/function and biology (review)

Mol Membr Biol. Oct-Dec 2000;17(4):189-200. doi: 10.1080/09687680010009646.

Abstract

This review examines the structure and function of the sarco(endo)plasmic reticulum calcium pump (SERCA1a) in the light of the recent publication of the 2.6 A resolution structure of this protein, and looks at the increasing awareness of the key role played by SERCAs in calcium signalling. The roles played by the calcium pump isoforms, SERCA1a/b, SERCA2a/b and SERCA3a/b/c in cellular function are discussed, and the modulation of SERCA activity by phospholamban, sarcolipin and other modulatory influences is examined. The recent discoveries of human SERCA mutations leading to disease states is reviewed, and the insights into SERCA function using transgenic approaches are outlined.

Publication types

  • Review

MeSH terms

  • Animals
  • Calcium Signaling
  • Calcium-Binding Proteins / chemistry
  • Calcium-Binding Proteins / genetics
  • Calcium-Binding Proteins / physiology
  • Calcium-Transporting ATPases / chemistry*
  • Calcium-Transporting ATPases / genetics
  • Calcium-Transporting ATPases / physiology*
  • Endoplasmic Reticulum / physiology*
  • Genetic Diseases, Inborn / enzymology
  • Genetic Diseases, Inborn / genetics
  • Humans
  • Mice
  • Mice, Knockout
  • Models, Molecular
  • Muscle Proteins / chemistry
  • Muscle Proteins / genetics
  • Muscle Proteins / physiology
  • Mutation
  • Proteolipids / chemistry
  • Proteolipids / genetics
  • Proteolipids / physiology
  • Sarcoplasmic Reticulum / physiology*
  • Sarcoplasmic Reticulum Calcium-Transporting ATPases

Substances

  • Calcium-Binding Proteins
  • Muscle Proteins
  • Proteolipids
  • phospholamban
  • sarcolipin
  • Sarcoplasmic Reticulum Calcium-Transporting ATPases
  • Calcium-Transporting ATPases