Abstract
Haliangicin, a novel beta-methoxyacrylate antibiotic with a conjugated tetraene moiety, was isolated from the culture broth of a marine myxobacterium. A bacterium tentatively named as Haliangium luteum required 2-3% NaCl for the growth and production of haliangicin. Haliangicin inhibits the growth of a wide spectrum of fungi but was inactive against bacteria. In mitochondrial respiratory chains, haliangicin interfered the electron flow within the cytochrome b-c1 segment.
MeSH terms
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Antifungal Agents / isolation & purification*
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Antifungal Agents / metabolism
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Antifungal Agents / pharmacology
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Electron Transport / drug effects
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Fatty Acids, Unsaturated / isolation & purification*
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Fatty Acids, Unsaturated / metabolism
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Fatty Acids, Unsaturated / pharmacology
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Fermentation
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Marine Biology
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Microbial Sensitivity Tests
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Molecular Structure
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NAD / metabolism
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Proteobacteria / metabolism*
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Spectrophotometry, Ultraviolet
Substances
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Antifungal Agents
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Fatty Acids, Unsaturated
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haliangicin
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NAD