Two functional channels from primary visual cortex to dorsal visual cortical areas

Science. 2001 Apr 13;292(5515):297-300. doi: 10.1126/science.1057916.


Relationships between the M and P retino-geniculo-cortical visual pathways and "dorsal" visual areas were investigated by measuring the sources of local excitatory input to individual neurons in layer 4B of primary visual cortex. We found that contributions of the M and P pathways to layer 4B neurons are dependent on cell type. Spiny stellate neurons receive strong M input through layer 4Calpha and no significant P input through layer 4Cbeta. In contrast, pyramidal neurons in layer 4B receive strong input from both layers 4Calpha and 4Cbeta. These observations, along with evidence that direct input from layer 4B to area MT arises predominantly from spiny stellates, suggest that these different cell types constitute two functionally specialized subsystems.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Brain Mapping
  • Dendrites / physiology
  • Excitatory Postsynaptic Potentials
  • In Vitro Techniques
  • Macaca
  • Motion Perception / physiology
  • Neural Inhibition
  • Neurons / physiology*
  • Patch-Clamp Techniques
  • Photic Stimulation
  • Pyramidal Cells / physiology*
  • Synapses / physiology
  • Visual Cortex / cytology
  • Visual Cortex / physiology*
  • Visual Pathways / physiology*
  • Visual Perception / physiology