Major trauma in elderly adults receiving lipid-lowering medications

J Trauma. 2001 Apr;50(4):678-83. doi: 10.1097/00005373-200104000-00014.


Background: Some clinical trials, laboratory experiments, and in vitro studies suggest that lipid-lowering medications predispose a person to traumatic injury.

Methods: We used population-based administrative database analysis to study adults age 65 years or more over a 5-year interval (n = 1,348,259).

Results: About 12% of the cohort received a prescription for a lipid-lowering medication and about 88% did not. The two groups had similar distributions of age, gender, and income. Overall, 2,557 (0.2%) were hospitalized for major trauma. Those who received a lipid-lowering medication were 39% less likely to sustain a major trauma than those who did not receive such medication (95% confidence interval, 29 to 47). Similar results were observed after adjustment for age, gender, and income; cardiac and neurologic medications; and lethality. No other cardiac or neurologic medication was associated with an apparent safety advantage.

Conclusion: Lipid-lowering medications do not lead to a clinically important increase in the absolute risk of major trauma for elderly patients in the community.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Age Distribution
  • Aged
  • Aged, 80 and over
  • Bias
  • Comorbidity
  • Drug Prescriptions / statistics & numerical data
  • Female
  • Hospitalization / statistics & numerical data
  • Humans
  • Hypolipidemic Agents / adverse effects*
  • Income / statistics & numerical data
  • Life Style
  • Male
  • Multiple Trauma / chemically induced*
  • Multiple Trauma / epidemiology*
  • Ontario / epidemiology
  • Population Surveillance
  • Registries
  • Risk Factors


  • Hypolipidemic Agents